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A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1
The lipid second messenger ceramide regulates the rate of β cleavage of the Alzheimer's disease APP (amyloid precursor protein) by affecting the molecular stability of the β secretase BACE1 (β-site APP cleaving enzyme 1). Such an event is stimulated in the brain by the normal process of aging,...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Portland Press Ltd.
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275071/ https://ncbi.nlm.nih.gov/pubmed/17425515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070040 |
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