Proteomic Assessment Shows That Many Endoplasmic Reticulum (ER)-resident Proteins Are Targeted by N(ϵ)-Lysine Acetylation in the Lumen of the Organelle and Predicts Broad Biological Impact

In addition to the nucleus, cytosol, and mitochondrial lumen, N(ϵ)-lysine acetylation also occurs in the lumen of the endoplasmic reticulum (ER). However, the impact of such an event on ER functions is still unknown. Here, we analyzed the “ER acetyl-lysine proteome” by nano-LC-MS/MS and discovered t...

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Bibliografiska uppgifter
Huvudupphovsmän: Pehar, Mariana, Lehnus, Massimiliano, Karst, Anna, Puglielli, Luigi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391156/
https://ncbi.nlm.nih.gov/pubmed/22628546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C112.362871
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