Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury

Systemic sclerosis (SSc), or scleroderma, similar to many fibrotic disorders, lacks effective therapies. Current trials focus on anti-inflammatory drugs or targeted approaches aimed at one of the many receptor mechanisms initiating fibrosis. In light of evidence that a myocardin-related transcriptio...

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Detalhes bibliográficos
Main Authors: Haak, Andrew J., Tsou, Pei-Suen, Amin, Mohammad A., Ruth, Jeffrey H., Campbell, Phillip, Fox, David A., Khanna, Dinesh, Larsen, Scott D., Neubig, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019321/
https://ncbi.nlm.nih.gov/pubmed/24706986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.213520
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