Quantification of Deaminase Activity-Dependent and -Independent Restriction of HIV-1 Replication Mediated by APOBEC3F and APOBEC3G through Experimental-Mathematical Investigation

APOBEC3F and APOBEC3G cytidine deaminases potently inhibit human immunodeficiency virus type 1 (HIV-1) replication by enzymatically inserting G-to-A mutations in viral DNA and/or impairing viral reverse transcription independently of their deaminase activity. Through experimental and mathematical in...

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Main Authors: Kobayashi, Tomoko, Koizumi, Yoshiki, Takeuchi, Junko S., Misawa, Naoko, Kimura, Yuichi, Morita, Satoru, Aihara, Kazuyuki, Koyanagi, Yoshio, Iwami, Shingo, Sato, Kei
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019142/
https://ncbi.nlm.nih.gov/pubmed/24623435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00062-14
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