Myogenic Enhancers Regulate Expression of the Facioscapulohumeral Muscular Dystrophy-Associated DUX4 Gene

Facioscapulohumeral muscular dystrophy (FSHD) is linked to epigenetic dysregulation of the chromosome 4q35 D4Z4 macrosatellite. However, this does not account for the tissue specificity of FSHD pathology, which requires stable expression of an alternative full-length mRNA splice form of DUX4 (DUX4-f...

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Hlavní autoři: Himeda, Charis L., Debarnot, Céline, Homma, Sachiko, Beermann, Mary Lou, Miller, Jeffrey B., Jones, Peter L., Jones, Takako I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019064/
https://ncbi.nlm.nih.gov/pubmed/24636994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00149-14
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