Nuclear translocation of Nuclear Factor of Activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus

Nuclear Factor of Activated T cells (NFAT) is a family of transcription factors involved in regulating the immune response. The canonical NFAT pathway is calcium-dependent and upon activation, NFAT is dephosphorylated by the phosphatase, calcineurin. This results in its translocation from the cytopl...

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Main Authors: Maguire, Orla, Tornatore, Kathleen M., O'Loughlin, Kieran L., Venuto, Rocco C., Minderman, Hans
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018210/
https://ncbi.nlm.nih.gov/pubmed/24136923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.22401
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