REGION-SPECIFIC NEURON AND SYNAPSE LOSS IN THE HIPPOCAMPUS OF APP(SL)/PS1 KNOCK-IN MICE

Transgenic mouse models with knock-in (KI) expression of human mutant amyloid precursor protein (APP) and/or human presenilin 1 (PS1) may be helpful to elucidate the cellular consequences of APP and PS1 misprocessing in the aging brain. Age-related alterations in total numbers of neurons and in numb...

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Autors principals: Brasnjevic, Ivona, Lardenoije, Roy, Schmitz, Christoph, Van Der Kolk, Nicolien, Dickstein, Dara L., Takahashi, Hisaaki, Hof, Patrick R., Steinbusch, Harry W.M., Rutten, Bart P.F.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018205/
https://ncbi.nlm.nih.gov/pubmed/24829793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s13380-013-0111-8
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