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Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases

According to a long-standing hypothesis, aging is mainly caused by accumulation of nuclear (n) DNA damage in differentiated cells such as neurons due to insufficient nDNA repair during lifetime. In line with this hypothesis it was until recently widely accepted that neuron loss is a general conseque...

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Detalhes bibliográficos
Main Authors: Brasnjevic, Ivona, Hof, Patrick R., Steinbusch, Harry W.M., Schmitz, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919205/
https://ncbi.nlm.nih.gov/pubmed/18458001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.03.010
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