N-Methylated sst(2) Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation

[Image: see text] A focused multiply N-methylated library of a cyclic hexapeptidic somatostatin analogue: MK678 cyclo(−MeAYwKVF−) was generated, which resulted in the unexpected observation of an efficacious tetra-N-methylated analogue, cyclo(−MeAYMewMeKVMeF−) with a potent inhibitory action on sens...

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Detalhes bibliográficos
Main Authors: Chatterjee, Jayanta, Laufer, Burkhardt, Beck, Johannes G., Helyes, Zsuzsanna, Pintér, Erika, Szolcsányi, János, Horvath, Aniko, Mandl, Jozsef, Reubi, Jean C., Kéri, György, Kessler, Horst
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018149/
https://ncbi.nlm.nih.gov/pubmed/24900340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200032v
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