A Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques

[Image: see text] (18)F-labeled imidazo[2,1-b]benzothiazole ([(18)F]8) was synthesized and evaluated as a tracer for cerebral β-amyloid deposits (Aβ) by means of positron emission tomography (PET). [(18)F]8 exhibits a high affinity to Aβ and suitable brain uptake kinetics combined with a high metabo...

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Bibliografske podrobnosti
Main Authors: Yousefi, Behrooz H., Drzezga, Alexander, von Reutern, Boris, Manook, André, Schwaiger, Markus, Wester, Hans-Jürgen, Henriksen, Gjermund
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2011
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018122/
https://ncbi.nlm.nih.gov/pubmed/24900362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200123w
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