Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars

[Image: see text] Glucosylceramide synthase (GCS) is an important target for clinical drug development for the treatment of lysosomal storage disorders and a promising target for combating type 2 diabetes. Iminosugars are useful leads for the development of GCS inhibitors; however, the effective imi...

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मुख्य लेखकों: Ghisaidoobe, Amar, Bikker, Pieter, de Bruijn, Arjan C. J., Godschalk, Frithjof D., Rogaar, Eva, Guijt, Marieke C., Hagens, Peter, Halma, Jerre M., van't Hart, Steven M., Luitjens, Stijn B., van Rixel, Vincent H. S., Wijzenbroek, Mark, Zweegers, Thor, Donker-Koopman, Wilma E., Strijland, Anneke, Boot, Rolf, van der Marel, Gijs, Overkleeft, Herman S., Aerts, Johannes M. F. G., van den Berg, Richard J. B. H. N.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2010
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017989/
https://ncbi.nlm.nih.gov/pubmed/24900289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100192b
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