Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars

[Image: see text] Glucosylceramide synthase (GCS) is an important target for clinical drug development for the treatment of lysosomal storage disorders and a promising target for combating type 2 diabetes. Iminosugars are useful leads for the development of GCS inhibitors; however, the effective imi...

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Main Authors: Ghisaidoobe, Amar, Bikker, Pieter, de Bruijn, Arjan C. J., Godschalk, Frithjof D., Rogaar, Eva, Guijt, Marieke C., Hagens, Peter, Halma, Jerre M., van't Hart, Steven M., Luitjens, Stijn B., van Rixel, Vincent H. S., Wijzenbroek, Mark, Zweegers, Thor, Donker-Koopman, Wilma E., Strijland, Anneke, Boot, Rolf, van der Marel, Gijs, Overkleeft, Herman S., Aerts, Johannes M. F. G., van den Berg, Richard J. B. H. N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2010
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017989/
https://ncbi.nlm.nih.gov/pubmed/24900289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100192b
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