Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS)

[Image: see text] Rapid triaging of three series of related hits selected from the Tres Cantos Anti-Malarial Set (TCAMS) are described. A triazolopyrimidine series was deprioritized due to delayed inhibition of parasite growth. A lactic acid series has derivatives with IC(50) < 500 nM in a standa...

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Detalhes bibliográficos
Main Authors: Rueda, Lourdes, Castellote, Isabel, Castro-Pichel, Julia, Chaparro, Maria J., de la Rosa, Juan Carlos, Garcia-Perez, Adolfo, Gordo, Mariola, Jimenez-Diaz, Maria Belen, Kessler, Albane, Macdonald, Simon J.F., Martinez, Maria Santos, Sanz, Laura M., Gamo, Francisco Javier, Fernandez, Esther
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017974/
https://ncbi.nlm.nih.gov/pubmed/24900273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001517
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