Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium

Crystal structures of factor (F) VIIa/soluble (s) tissue factor (TF), obtained under high Mg(2+) (50 mM Mg(2+)/5 mM Ca(2+)), have three of seven Ca(2+)-sites in the γ-Carboxyglutamic Acid (Gla) domain replaced by Mg(2+) at positions 1, 4 and 7. We now report structures under low Mg(2+) (2.5 mM Mg(2+...

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Main Authors: Vadivel, Kanagasabai, Agah, Sayeh, Messer, Amanda S., Cascio, Duilio, Bajaj, Madhu S., Krishnaswamy, Sriram, Esmon, Charles T, Padmanabhan, Kaillathe, Bajaj, S. Paul
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017951/
https://ncbi.nlm.nih.gov/pubmed/23454357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.02.017
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