Quantifying Vitamin K-dependent Holoprotein Compaction caused by differential γ-carboxylation using HPSEC

This study uses high-pressure size exclusion chromatography (HPSEC) to quantify divalent metal ion (X(2+))-induced compaction found in vitamin K dependent (VKD) proteins. Multiple X(2+) binding sites formed by the presence of up to 12 -carboxyglutamic acid residues (Gla) are present in plasma-derive...

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Vydáno v:Anal Biochem
Hlavní autoři: Vanderslice, Nicholas C., Messer, Amanda S., Vadivel, Kanagasabai, Bajaj, S. Paul, Phillips, Martin, Fatemi, Mostafa, Xu, Weijie, Velander, William H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428943/
https://ncbi.nlm.nih.gov/pubmed/25804408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2015.03.019
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