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The E3 Ligase CHIP: Insights into Its Structure and Regulation

The carboxy-terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase containing three tandem repeats of tetratricopeptide (TPR) motifs and a C-terminal U-box domain separated by a charged coiled-coil region. CHIP is known to function as a central quality control E3 ligase and regulate...

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Detalhes bibliográficos
Main Authors: Paul, Indranil, Ghosh, Mrinal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017836/
https://ncbi.nlm.nih.gov/pubmed/24868554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/918183
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