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Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP

Dominantly inherited mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common cause of familial Parkinson's disease (PD) and have also been identified in individuals with sporadic PD. Although the exact cellular function of LRRK2 remains unknown, most PD-linked mutations a...

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Detalles Bibliográficos
Main Authors: Ding, Xiaodong, Goldberg, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694275/
https://ncbi.nlm.nih.gov/pubmed/19536328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005949
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