Therapeutic Efficacy of Potent Neutralizing HIV-1-Specific Monoclonal Antibodies in SHIV-Infected Rhesus Monkeys

HIV-1-specific monoclonal antibodies (mAbs) with extraordinary potency and breadth have recently been described. In humanized mice, combinations of mAbs have been shown to suppress viremia, but the therapeutic potential of these mAbs has not yet been evaluated in primates with an intact immune syste...

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Detalhes bibliográficos
Main Authors: Barouch, Dan H., Whitney, James B., Moldt, Brian, Klein, Florian, Oliveira, Thiago Y., Liu, Jinyan, Stephenson, Kathryn E., Chang, Hui-Wen, Shekhar, Karthik, Gupta, Sanjana, Nkolola, Joseph P., Seaman, Michael S., Smith, Kaitlin M., Borducchi, Erica N., Cabral, Crystal, Smith, Jeffrey Y., Blackmore, Stephen, Sanisetty, Srisowmya, Perry, James R., Beck, Matthew, Lewis, Mark G., Rinaldi, William, Chakraborty, Arup K., Poignard, Pascal, Nussenzweig, Michel C., Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017780/
https://ncbi.nlm.nih.gov/pubmed/24172905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12744
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