Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the Rho family GTPases Rac and Cdc42 that regulate actin cytoskeletal remodeling, but its role in the immune system remains poorly understood. I...

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Bibliografiske detaljer
Main Authors: Phee, Hyewon, Au-Yeung, Byron B, Pryshchep, Olga, O'Hagan, Kyle Leonard, Fairbairn, Stephanie Grace, Radu, Maria, Kosoff, Rachelle, Mollenauer, Marianne, Cheng, Debra, Chernoff, Jonathan, Weiss, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2014
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017645/
https://ncbi.nlm.nih.gov/pubmed/24843022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02270
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