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Bioretrosynthetic construction of a didanosine biosynthetic pathway
Concatenation of engineered biocatalysts into multistep pathways dramatically increases their utility, but development of generalizable assembly methods remains a significant challenge. Herein we evaluate ‘bioretrosynthesis’, which is an application of the retrograde evolution hypothesis, for biosyn...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017637/ https://ncbi.nlm.nih.gov/pubmed/24657930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1494 |
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