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Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis

To address the synthesis of increasingly structurally diverse small-molecule drugs, methods for the generation of efficient and selective biological catalysts are becoming increasingly important. ‘Directed evolution’ is an umbrella term referring to a variety of methods for improving or altering the...

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Main Authors: Nannemann, David P, Birmingham, William R, Scism, Robert A, Bachmann, Brian O
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155183/
https://ncbi.nlm.nih.gov/pubmed/21644826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.11.48
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