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Design and directed evolution of a dideoxy purine nucleoside phosphorylase

Purine nucleoside phosphorylase (PNP) catalyzes the synthesis and phosphorolysis of purine nucleosides, interconverting nucleosides with their corresponding purine base and ribose-1-phosphate. While PNP plays significant roles in human and pathogen physiology, we are interested in developing PNP as...

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Detalhes bibliográficos
Main Authors: Nannemann, David P., Kaufmann, Kristian W., Meiler, Jens, Bachmann, Brian O.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898500/
https://ncbi.nlm.nih.gov/pubmed/20525731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzq033
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