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Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

[Image: see text] Many cellular proteins are ‘disordered’ in isolation. A subset of these intrinsically disordered proteins (IDPs) can, upon binding another molecule, fold to a well-defined three-dimensional structure. In the structurally heterogeneous, unbound ensemble of these IDPs, conformations...

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Main Authors: Rogers, Joseph M., Wong, Chi T., Clarke, Jane
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017604/
https://ncbi.nlm.nih.gov/pubmed/24654952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4125065
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