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Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1
PUMA, which belongs to the BH3-only protein family, is an intrinsically disordered protein (IDP). It binds to its cellular partner Mcl-1 through its BH3 motif, which folds upon binding into an α helix. We have applied a structure-based coarse-grained model, with an explicit Debye—Hückel charge model...
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| Published in: | PLoS Comput Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5400261/ https://ncbi.nlm.nih.gov/pubmed/28369057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005468 |
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