Ly-6C(high) Monocytes Depend on Nr4a1 to Balance both Inflammatory and Reparative Phases in the Infarcted Myocardium

RATIONALE: Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6C(high) and reparative Ly-6C(low) monocytes/macrophages (Mo/MΦ). According to one model, Mo/MΦ heterogeneity in the heart originates in the blood and involves the sequential recruitment of dist...

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Main Authors: Hilgendorf, Ingo, Gerhardt, Louisa M. S., Tan, Timothy C., Winter, Carla, Holderried, Tobias A. W., Chousterman, Benjamin G., Iwamoto, Yoshiko, Liao, Ronglih, Zirlik, Andreas, Scherer-Crosbie, Marielle, Hedrick, Catherine C., Libby, Peter, Nahrendorf, Matthias, Weissleder, Ralph, Swirski, Filip K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017349/
https://ncbi.nlm.nih.gov/pubmed/24625784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.303204
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