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Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines
[Image: see text] Herein, we demonstrate the design, synthesis, biophysical properties, and preliminary biological evaluation of 6-substituted indenoisoquinolines as a new class of G-quadruplex stabilizing small molecule ligands. We have synthesized 6-substituted indenoisoquinolines 1a−e in two step...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017300/ https://ncbi.nlm.nih.gov/pubmed/24900212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100062z |
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