Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

Gelijkaardige items

• Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val
  door: Sharma, Prem L., et al.
  Gepubliceerd in: (1999)
• A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus
  door: Chunduri, HimaBindu, et al.
  Gepubliceerd in: (2011)
• Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
  door: Boyer, Paul L., et al.
  Gepubliceerd in: (2019)
• Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication.
  door: Kleim, J P, et al.
  Gepubliceerd in: (1993)
• Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
  door: Balzarini, J, et al.
  Gepubliceerd in: (1994)