A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

BACKGROUND: The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1) includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT) is essential for HIV-1 replication, several nucleoside analogues have bee...

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Main Authors: Chunduri, HimaBindu, Rimland, David, Nurpeisov, Viktoria, Crumpacker, Clyde S, Sharma, Prem L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038945/
https://ncbi.nlm.nih.gov/pubmed/21255423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-33
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