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Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4- dihydroquinoxaline-2(1H)-thione (HBY 097) was used to select for drug-resistant HIV-1 variants in vitro. The viruses first developed mutations affecting the NNRTI-binding pocket, and five...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kleim, J P, Rösner, M, Winkler, I, Paessens, A, Kirsch, R, Hsiou, Y, Arnold, E, Riess, G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40173/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8552634/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.1.34
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