A novel role of IL-17–producing lymphocytes in mediating lytic bone disease in multiple myeloma

Osteoclast (OC)–mediated lytic bone disease remains a cause of major morbidity in multiple myeloma. Here we demonstrate the critical role of interleukin-17–producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients. Unlike MILs from normal b...

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Autors principals: Noonan, Kimberly, Marchionni, Luigi, Anderson, Judy, Pardoll, Drew, Roodman, G. David, Borrello, Ivan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017298/
https://ncbi.nlm.nih.gov/pubmed/20664052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-283895
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