S1P promotes murine progenitor cell egress and mobilization via S1P(1)-mediated ROS signaling and SDF-1 release

The mechanisms of hematopoietic progenitor cell egress and clinical mobilization are not fully understood. Herein, we report that in vivo desensitization of Sphingosine-1-phosphate (S1P) receptors by FTY720 as well as disruption of S1P gradient toward the blood, reduced steady state egress of immatu...

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Hauptverfasser: Golan, Karin, Vagima, Yaron, Ludin, Aya, Itkin, Tomer, Cohen-Gur, Shiri, Kalinkovich, Alexander, Kollet, Orit, Kim, Chihwa, Schajnovitz, Amir, Ovadya, Yossi, Lapid, Kfir, Shivtiel, Shoham, Morris, Andrew J., Ratajczak, Mariusz Z., Lapidot, Tsvee
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017293/
https://ncbi.nlm.nih.gov/pubmed/22279055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-358614
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