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Atomic-resolution monitoring of protein maturation in live human cells by NMR
We used NMR directly in live human cells to describe the complete post-translational maturation process of human superoxide dismutase 1 (SOD1). We could follow, at atomic resolution, zinc binding, homodimer formation and copper uptake, and discover that copper chaperone for SOD1 (CCS) oxidation of t...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017183/ https://ncbi.nlm.nih.gov/pubmed/23455544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1202 |
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