Atomic-resolution monitoring of protein maturation in live human cells by NMR

We used NMR directly in live human cells to describe the complete post-translational maturation process of human superoxide dismutase 1 (SOD1). We could follow, at atomic resolution, zinc binding, homodimer formation and copper uptake, and discover that copper chaperone for SOD1 (CCS) oxidation of t...

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Bibliographic Details
Main Authors: Banci, Lucia, Barbieri, Letizia, Bertini, Ivano, Luchinat, Enrico, Secci, Erica, Zhao, Yuguang, Aricescu, A. Radu
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017183/
https://ncbi.nlm.nih.gov/pubmed/23455544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1202
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