Genetically engineered endostatin-lidamycin fusion proteins effectively inhibit tumor growth and metastasis

BACKGROUND: Endostatin (ES) inhibits endothelial cell proliferation, migration, invasion, and tube formation. It also shows antiangiogenesis and antitumor activities in several animal models. Endostatin specifically targets tumor vasculature to block tumor growth. Lidamycin (LDM), which consists of...

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Bibliografiske detaljer
Main Authors: Jiang, Wen-guo, Lu, Xin-an, Shang, Bo-yang, Fu, Yan, Zhang, Sheng-hua, Zhou, Daifu, Li, Liang, Li, Yi, Luo, Yongzhang, Zhen, Yong-su
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016579/
https://ncbi.nlm.nih.gov/pubmed/24128285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-479
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