Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells

Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are still poorly understood, many studies point towards t...

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Autors principals: Opyrchal, Mateusz, Salisbury, Jeffrey L., Zhang, Shuya, McCubrey, James, Hawse, John, Goetz, Mattew P., Lomberk, Gwen A., Haddad, Tufia, Degnim, Amy, Lange, Carol, Ingle, James N., Galanis, Evanthia, D'Assoro, Antonino B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016211/
https://ncbi.nlm.nih.gov/pubmed/24816249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096995
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