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Tumor hypoxia as a driving force in genetic instability

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy. Hypoxia also leads to altered transcription and translation of a...

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Autors principals: Luoto, Kaisa R, Kumareswaran, Ramya, Bristow, Robert G
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016142/
https://ncbi.nlm.nih.gov/pubmed/24152759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2041-9414-4-5
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