Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons

BACKGROUND: A luminex-based screen of cytokine expression in dorsal root ganglia (DRG) and nerve of type 1 diabetic rodents revealed interleukin-1 (IL-1α) and IL-1β to be significantly depressed. We, therefore, tested the hypothesis that impaired IL-1α and IL-1β expression in DRG may contribute to a...

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Autores principales: Saleh, Ali, Roy Chowdhury, Subir K, Smith, Darrell R, Balakrishnan, Savitha, Tessler, Lori, Schartner, Emily, Bilodeau, Andre, Van Der Ploeg, Randy, Fernyhough, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016027/
https://ncbi.nlm.nih.gov/pubmed/24152426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-45
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