Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

Diabetes causes mitochondrial dysfunction in sensory neurons that may contribute to peripheral neuropathy. Ciliary neurotrophic factor (CNTF) promotes sensory neuron survival and axon regeneration and prevents axonal dwindling, nerve conduction deficits and thermal hypoalgesia in diabetic rats. In t...

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Autori principali: Saleh, Ali, Roy Chowdhury, Subir K., Smith, Darrel R., Balakrishnan, Savitha, Tessler, Lori, Martens, Corina, Morrow, Dwane, Schartner, Emily, Frizzi, Katie E., Calcutt, Nigel A., Fernyhough, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521091/
https://ncbi.nlm.nih.gov/pubmed/23022047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.09.015
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