Stress-induced cleavage of Myc promotes cancer cell survival

Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated proteolysis of Myc. This generates Myc-nick, a cytoplasmic, transcriptionally inactive cleavage product of Myc. We found conversion of Myc into...

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Bibliografiska uppgifter
Huvudupphovsmän: Conacci-Sorrell, Maralice, Ngouenet, Celine, Anderson, Sarah, Brabletz, Thomas, Eisenman, Robert N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2014
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015487/
https://ncbi.nlm.nih.gov/pubmed/24696454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.231894.113
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