PI3K pathway activation in high-grade ductal carcinoma in situ—implications for progression to invasive breast carcinoma

PURPOSE: To assess the prevalence of phosphoinositide 3-kinase (PI3K) pathway alterations in pure high-grade ductal carcinoma in situ (DCIS) and DCIS associated with invasive breast cancer (IBC), and to determine whether DCIS and adjacent IBCs harbor distinct PI3K pathway aberrations. EXPERIMENTAL D...

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Autors principals: Sakr, Rita A., Weigelt, Britta, Chandarlapaty, Sarat, Andrade, Victor P., Guerini-Rocco, Elena, Giri, Dilip, Ng, Charlotte K. Y., Cowell, Catherine F., Rosen, Neal, Reis-Filho, Jorge S., King, Tari A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015460/
https://ncbi.nlm.nih.gov/pubmed/24634376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2267
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