Modified Lentiviral LTRs Allow Flp Recombinase–mediated Cassette Exchange and In Vivo Tracing of “Factor-free” Induced Pluripotent Stem Cells

Methods for generating induced pluripotent stem cells (iPSCs) for disease modeling and cell therapies have progressed from integrating vectors to transient delivery of reprogramming factors, avoiding permanent genomic modification. A major limitation of unmodified iPSCs is the assessment of their di...

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Dettagli Bibliografici
Autori principali: Kuehle, Johannes, Turan, Soeren, Cantz, Tobias, Hoffmann, Dirk, Suerth, Julia D, Maetzig, Tobias, Zychlinski, Daniela, Klein, Christoph, Steinemann, Doris, Baum, Christopher, Bode, Juergen, Schambach, Axel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015239/
https://ncbi.nlm.nih.gov/pubmed/24434935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.4
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