Modified Lentiviral LTRs Allow Flp Recombinase–mediated Cassette Exchange and In Vivo Tracing of “Factor-free” Induced Pluripotent Stem Cells

Methods for generating induced pluripotent stem cells (iPSCs) for disease modeling and cell therapies have progressed from integrating vectors to transient delivery of reprogramming factors, avoiding permanent genomic modification. A major limitation of unmodified iPSCs is the assessment of their di...

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Main Authors: Kuehle, Johannes, Turan, Soeren, Cantz, Tobias, Hoffmann, Dirk, Suerth, Julia D, Maetzig, Tobias, Zychlinski, Daniela, Klein, Christoph, Steinemann, Doris, Baum, Christopher, Bode, Juergen, Schambach, Axel
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015239/
https://ncbi.nlm.nih.gov/pubmed/24434935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.4
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