Modified Lentiviral LTRs Allow Flp Recombinase–mediated Cassette Exchange and In Vivo Tracing of “Factor-free” Induced Pluripotent Stem Cells

Methods for generating induced pluripotent stem cells (iPSCs) for disease modeling and cell therapies have progressed from integrating vectors to transient delivery of reprogramming factors, avoiding permanent genomic modification. A major limitation of unmodified iPSCs is the assessment of their di...

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Autores principales: Kuehle, Johannes, Turan, Soeren, Cantz, Tobias, Hoffmann, Dirk, Suerth, Julia D, Maetzig, Tobias, Zychlinski, Daniela, Klein, Christoph, Steinemann, Doris, Baum, Christopher, Bode, Juergen, Schambach, Axel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015239/
https://ncbi.nlm.nih.gov/pubmed/24434935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.4
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