Tropism-modified AAV Vectors Overcome Barriers to Successful Cutaneous Therapy

Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment and survival of transplants. Although efficacious in keratinocyte-directed gene transfer, retro-/lentiviral vectors may raise s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sallach, Jessica, Di Pasquale, Giovanni, Larcher, Fernando, Niehoff, Nadine, Rübsam, Matthias, Huber, Anke, Chiorini, Jay, Almarza, David, Eming, Sabine A, Ulus, Hikmet, Nishimura, Stephen, Hacker, Ulrich T, Hallek, Michael, Niessen, Carien M, Büning, Hildegard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015237/
https://ncbi.nlm.nih.gov/pubmed/24468915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.14
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