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Vector and Helper Genome Rearrangements Occur During Production of Helper-Dependent Adenoviral Vectors
Helper-dependent adenoviral vectors (HD Ad) hold extreme promise for gene therapy of human diseases. All viral genes are deleted in HD Ad vectors, and therefore, the presence of a helper virus is required for their production. Current methods to minimize helper contamination in large-scale preparati...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Mary Ann Liebert, Inc.
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4015077/ https://ncbi.nlm.nih.gov/pubmed/23249343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.198 |
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