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Vector and Helper Genome Rearrangements Occur During Production of Helper-Dependent Adenoviral Vectors

Helper-dependent adenoviral vectors (HD Ad) hold extreme promise for gene therapy of human diseases. All viral genes are deleted in HD Ad vectors, and therefore, the presence of a helper virus is required for their production. Current methods to minimize helper contamination in large-scale preparati...

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Dettagli Bibliografici
Autori principali: Ahn, Miwon, Gamble, Aisha, Witting, Scott R., Magrisso, Jack, Surendran, Sneha, Obici, Silvana, Morral, Núria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015077/
https://ncbi.nlm.nih.gov/pubmed/23249343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.198
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