Anomeric DNA quadruplexes: Modified thrombin aptamers

Thrombin-binding aptamer (TBA) is a 15-nt DNA oligomer that efficiently inhibits thrombin. It has been shown that TBA folds into an anti-parallel unimolecular G-quadruplex. Its three-dimensional chair-like structure consists of two G-tetrads connected by TT and TGT loops. TBA undergoes fast degradat...

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Bibliographic Details
Main Authors: Kolganova, Natalia A, Varizhuk, Anna M, Novikov, Roman A, Florentiev, Vladimir L, Pozmogova, Galina E, Borisova, Olga F, Shchyolkina, Anna K, Smirnov, Igor P, Kaluzhny, Dmitry N, Timofeev, Edward N
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014524/
https://ncbi.nlm.nih.gov/pubmed/25483931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/adna.28422
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