Comparison of the ‘Chemical’ and ‘Structural’ Approaches to the Optimization of the Thrombin-Binding Aptamer

Noncanonically structured DNA aptamers to thrombin were examined. Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer. These approaches are chemical modification and the addition of a duplex module to the aptamer core...

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Detalhes bibliográficos
Main Authors: Tatarinova, Olga, Tsvetkov, Vladimir, Basmanov, Dmitry, Barinov, Nikolay, Smirnov, Igor, Timofeev, Edward, Kaluzhny, Dmitry, Chuvilin, Andrey, Klinov, Dmitry, Varizhuk, Anna, Pozmogova, Galina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930721/
https://ncbi.nlm.nih.gov/pubmed/24586736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089383
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