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Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice

The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55...

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Autors principals: Krohn, Jon, Speed, Doug, Palme, Rupert, Touma, Chadi, Mott, Richard, Flint, Jonathan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014490/
https://ncbi.nlm.nih.gov/pubmed/24811081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096450
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