Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

The disease mechanism of Rett syndrome (RTT) is not well understood. Studies in RTT mouse models have suggested a non-cell-autonomous role for astrocytes in RTT pathogenesis. However, it is not clear whether this is also true for human RTT astrocytes. To establish an in vitro human RTT model, we pre...

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Detaylı Bibliyografya
Asıl Yazarlar: Williams, Emily Cunningham, Zhong, Xiaofen, Mohamed, Ahmed, Li, Ronghui, Liu, Yan, Dong, Qiping, Ananiev, Gene E., Mok, Jonathan Chern Choong, Lin, Benjamin Ray, Lu, Jianfeng, Chiao, Cassandra, Cherney, Rachel, Li, Hongda, Zhang, Su-Chun, Chang, Qiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014193/
https://ncbi.nlm.nih.gov/pubmed/24419315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu008
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